Acute Myeloid Leukemia Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation

1Department of Laboratory Medicine, University of California, San Francisco, CA, USA; 2Computational Biology Core, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA; 3Center for Cancer and Blood Disorders, Phoenix Children's Hospital, AZ, USA; 4Department of Pathology, University of Michigan, Ann Arbor, MI, USA; 5Institut Universitaire d’Hématologie, Université Paris-Diderot UMR 944/7212, France; and 6Department of Medicine, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA